IF . Cardiac and renal function are inextricably connected through both hemodynamic and neurohormonal mechanisms, and the interaction between these organ systems plays an important role in adaptive and pathophysiologic remodeling of the heart, as well as in the response to renally acting therapies. Download all styles. Only article types that appear in the drop-down menu during the submission process are available for submission to the selected section. Notably, the effect of these various conditions on myofilament and single fiber function tends to be larger in older women compared to older men, which may partially contribute to their higher rates of disability. Two polyclonal antibodies were generated (AQP4/1 and AQP4/2). Impact Score: 4.14 h-Index: 102 SJR: 1.32 Overall Ranking: 2807. Among gastrointestinal tumors, PDAC is one of the most malignant. Do Omega-3 Fatty Acids Have a Role in Prevention of Cardiovascular Disease? Some article types, such as those that mention medicine, are section specific. Recent interest in modeling acute alcohol exposure has yielded new insights into potential mechanisms of acute injury, which also may well be relevant for chronic ALD. Articles that address purely pathological processes or treatment/management of disease do not fall within the areas covered by Frontiers in Physiology. Journals. YKL-40 is a potent angiogenic factor capable of stimulating tumor vascularization mediated by endothelial cells and maintaining vascular integrity supported by smooth muscle cells. The analysis of the immune response by subtyping of liver infiltrating lymphocytes showed circumstantial evidence of adaptive immune reaction with CD 8 positive CTLs being the dominant lymphocyte population. As a result, this volume will open new avenues of inquiry as well as cross-disciplinary conversations for readers everywhere. Bioinformatics. In their colonies, there are different types of individuals, i.e., castes, which show distinctive phenotypes specialized in specific colony tasks. physiology@frontiersin.org, Tel +41(0)21 510 17 10 In just 4 years, it has become the second largest and the 4th most cited Physiology journal in the world. While low doses of Ang II (i.e., 50 and 100 ng/kg/min) had little to no effect on blood pressure or endothelial function, high doses of Ang II (e.g., 1000 ng/kg/min) were associated with large increases in arterial pressure and marked impairment of endothelial function. 5.516. Texcoco, Mexico). A better understanding of chemokine/chemokine receptor axes will therefore pave the way for development of novel targeted therapies for the treatment of liver disease. Clarivate Analytics has released its 2020 edition of the Journal Citation Reports, which gives journal impact factors and rankings of more than 11,000 scholarly journals.The 2019 impact factors of APS journals, along with a comparison of the past two years, are given in the table below. The Journal of Physiology publishes original Research Papers in all areas of physiology and pathophysiology illustrating new physiological principles or mechanisms. Due to the nature of our publishing program, sections cross-listed between two or more journals (for e.g. Contact Sales: +1-888-418-1937. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. More recently it has been appreciated that chemokines can have diverging effects depending on their temporal expression pattern and the type of injury. The trial was repeated during phentolamine infusion (α-adrenergic receptor blockade). This book provides researchers, decision makers, and other scientific stakeholders with a snapshot of the basics, the tools, and the underlying visions that drive the current scientific (r)evolution, often called ‘Open Science.’ Field Chief Editor Joshua L. Heazlewood at the University of Melbourne is supported by an outstanding Editorial . I/R was created by left anterior descending coronary artery occlusion for 45 min using a percutaneous over-the-wire balloon catheter. MK protein was injected as a bolus through the catheter at the initiation of reperfusion [MK-treated (MKT) group]. Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects, The Role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer’s disease, Characterization of Aquaporin 4 Protein Expression and Localization in Tissues of the Dogfish (Squalus acanthias), Cholesterol accelerates the binding of Alzheimer's β-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation, Angiotensin II-Induced Endothelial Dysfunction is Temporally Linked with Increases in Intereukin-6 and Vascular Macrophage Accumulation. Frontiers journals improved their Journal Impact Factor ranking in 30 out of 39 categories.. The impact factor (If), also denoted as Journal impact factor (JIF), of an academic journal is a . This similarity goes yet deeper, as hexokinase has two distinct functions both as an enzyme and as a sensor (“sensyme”), a duality that appears to be conserved from plants to fungi to animals (Frommer et al., 2003). With the aim of decoupling the effect of cholesterol on GM1 from direct Abeta-cholesterol interactions, we designed a minimal peptide (Abeta5-16) containing the GM1-binding domain but lacking the amino acid residues involved in cholesterol recognition. The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, and molecular levels. Such a well and tightly orchestrated regulation in TGF-β activity enables an immediate, highly localized response to type-specific tissue injury. Anticipating the natural prognosis of a patient with ALF is one of the most challenging tasks in hepatology critical care. The analysis of the immune response by subtyping of liver infiltrating lymphocytes indicates an adaptive mechanism suggesting in analogy with HAV, HBV and HCV that the virus itself is not cytopathic but liver damage is due to immune reaction. Room location, session times, format, and speakers are subject to change. Schools Details: Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Since its launch in 2010, it has become the #1 most cited and 2nd largest open-access journal in Physiology, and the #2 most cited amongst all journals in Physiology. The metric tide is certainly rising. Unlike King Canute, we have the agency and opportunity – and in this book, a serious body of evidence – to influence how it washes through higher education and research. Submission. The molecular mechanisms regulating the aggressive behavior of PDAC still remain to be clarified. Therefore, the regulation of locally activated TGF-β levels is increasingly recognized as a therapeutic target for liver fibrogenesis. ISSN: 0168-9452. All manuscripts must be submitted directly to the section Vascular Physiology, where they are peer-reviewed by the Associate and Review Editors of the specialty section. The structure of vascular networks adapts continuously to meet changes in demand of the surrounding tissue. Similarly, all articles with a research focus on genes and genomes should be submitted to an appropriate section of Frontiers in Genetics; these submissions will not be considered for review in Frontiers in Physiology. Peroxisomes are remarkably dynamic organelles that participate in a diverse array of cellular processes, including the metabolism of lipids and reactive oxygen species. Read Paper. physiology.editorial.office@frontiersin.org, For queries regarding Research Topics, Editorial Board applications, and journal development, please contact Journal: Frontiers in Physiology. Articles from Frontiers in Physiology are provided here courtesy of Frontiers Media SA. Frontiers describes itself as "a community-rooted, open-access academic publisher", and boasts a ~71,000 head strong "virtual editorial office". Note that 2020 Impact Factor are reported in 2021; they cannot be calculated until all of the 2020 publications have been . Again AQP4/1 antibody stained most or all the cell including the nucleus, whereas AQP4/2 had a plasma membrane and sometimes cytoplasmic distribution. Support. Most of the known vascular adaptation mechanisms are based on local reactions to local stimuli such as pressure and flow, which in turn reflects influence from the surrounding tissue. As stated, articles of this nature submitted to Frontiers in Physiology will be returned to authors without review, and/or with a suggestion to submit to a more appropriate Frontiers journal. Marine n-3 polyunsaturated fatty acids (PUFA) may have beneficial effects in relation to atrial fibrillation (AF) with promising data from experimental animal studies, however, results from studies in humans have been inconsistent. Some of the key issues highlighted include the current concepts of peroxisome removal, the peroxisome quality control mechanisms, the initial triggers for peroxisome degradation, the factors for dysfunctional peroxisome recognition, and the regulation of peroxisome homeostasis. Papers on work at the molecular level, cell membrane, single cells, tissues or organs and on systems physiology are all encouraged. This handbook sets the new standard for comprehensive multi-authored textbooks in the field of neuro-otology. In contrast, higher concentrations of NO derived from the use of the exogenous NO donor, DETA NONOate, effectively suppressed the expression of ICAM-1/VCAM-1 in response to TNFα and induced greater S-nitrosylation of IKKβ and p65. The section contains genetic and genomic resources for drought adaptation and methods for selection of drought-resistant varieties in rice. Frontiers is based in Lausanne, Switzerland, with other offices in London, Madrid, Seattle and Brussels. Editor-in-Chief Wataru SAKAMOTO. The dysfunction of the Neurovascular Unit (NVU) has been proposed to be causative in AD development, due to an impaired clearance of Aβ from the brain. Hepatotoxicity by acetaminophen for example leads to cellular necrosis and activation of Toll-like receptors while the inciting insult in ischemia reperfusion injury produces reactive oxygen species and subsequent production of pro-inflammatory chemokines. Glucagon, a key hormone in the regulation of glucose homeostasis, acts as a counter-regulatory hormone to insulin by promoting hepatic glucose output. Therefore, it is important to determin how IPMN progresses to malignant phenotype. On the other hand, IPMN of the pancreas is distinct from PDAC because of its intraductal growth in the main pancreatic duct or secondary branches with rare invasion and metastasis to distant organs. Please review our privacy policy. Chemokines are small molecular weight proteins primarily known to drive migration of immune cell populations. Read the full Report for Frontiers in Physiology here . Impact Factor. Advertisement. time to ahead-of-print publication . Here, we demonstrate that a single intracoronary injection of MK protein in swine hearts at the onset of reperfusion dramatically reduces infarct size and ameliorates systolic/diastolic LV function. Molecular dynamics simulations suggested that Abeta5-16 interacts with a cholesterol-stabilized dimer of GM1. You can find which Frontiers Journals have an impact factor and its value on this page. AICAR also increased PKA activity in a reversible fashion. As often the case within scientific research, the answer is not as straightforward as the question. In this bold new book, distinguished philosopher Isabelle Stengers shows that research is deeply intertwined with broader social interests, which means that science cannot race ahead in isolation but must learn instead to slow down. Impact Factor 4.566 | CiteScore 5.6More on impact ›. "This volume brings together an innovative set of readings of complex interactions between Australian Aboriginal people and colonisers. Supports. Results show AQP4 is expressed in both (and all) branchial Na,K ATPase and V-type ATPase expressing cells. Histopathology of the biopsies revealed a classic acute hepatitis with cholestatic features and in some cases confluent necrosis in zone 3. We suggest that the system is driven toward a critical state as a consequence of the ongoing parameter optimization, mimicking an evolutionary pressure on the system. Two types of large mitochondria-rich cells are known to exist in elasmobranches, that express either Na,K ATPase or V-type ATPase. Conclusion: This volume establishes the standard for those who need the latest and best information on the physiology of birds. Using rat primary VSM cells (VSMC), the AMPK agonist AICAR increased AMPK activity and phosphorylation of the catalytic Thr172 site on AMPK. 2020 Impact Factor: 4.733 (#13 in Physiology) 2020 5-Year Impact Factor: 4.528 2020 Cited Half-Life: 11.9 Years 2020 Scopus CiteScore: 7.1 (#31 in Physiology) Google Scholar h5-index: 49 (#9 in Physiology) Avg. Blind peer review. MSX2, a member of the homeobox genes family, is demonstrated to be the downstream target for ras signaling pathway and is expressed in a variety of carcinoma cells, suggesting its relevance to the development of ductal pancreatic tumors since pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary-mucinous neoplasia (IPMN) harbor frequent K-ras gene mutations. Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer's disease. The drug transporter ABCB1 directly transports Aβ from the brain into the blood circulation, whereas the cholesterol transporter ABCA1 neutralizes Aβ aggregation capacity in an Apolipoprotein E (ApoE)-dependent manner, facilitating Aβ subsequent elimination from the brain. Furthermore, these data suggest that AMPK may be modulated by PKA and that positive feedback may exist between these two systems. Frontiers' story began in 2007, with the first journal Frontiers in Neuroscience. For people, plants can seem like aliens. Most cited open-access journals in Endocrinology & Metabolism . Defects in the insulin-glucagon fine-tuning machinery may result in β-cell glucose incompetence, leading to unsuppressed glucagon secretion and subsequent hyperglycemia, which often occur under extreme conditions of glucose influx or efflux. It is apparently a consequence of evolution, where much remains to be learned about the first ancestors of multicellular green organisms and the mechanisms that had to evolve to allow for efficient photosynthesis, gas exchange, efficient mining of mineral nutrients and multicellularity. Physiology (formerly published as News in Physiological Science) publishes brief review articles on major physiological developments. In the present minireview, we will summarize the contribution of ABCB1, and ABCA1 at the NVU in Aβ clearance. Elevation of intracellular calcium by FGF2 is accompanied by nuclear translocation of NFATc3 and NFATc2 and by an increase in the number of MyoD positive cells per muscle fiber, both of which were attenuated by TRPC blocker SKF 96365. The studies have demonstrated a positive association between cellular content of omega-3 PUFA and HRV and supplementation with omega-3 PUFA seems to increase HRV which could be a possible explanation for decreased risk of arrhythmic events and SCD sometimes observed after omega-3 PUFA supplementation. 此外，Frontiers in Neuroscience journal series 作为神经科学领域被引次数最高的系列期刊，保持在该领域的领先优势；Frontiers in Immunology, Frontiers in Physiology, Frontiers in Microbiology, Frontiers in Plant Science, Frontiers in Psychology 等期刊均稳健增长，在各自领域内被引量排名第一。 In kidney a sub-set of tubules were stained which may represent intermediate tubule segments. Angiotensin II (Ang II) is associated with vascular hypertrophy, endothelial dysfunction and activation of a number of inflammatory molecules, however the linear events involved in the development of hypertension and endothelial dysfunction produced in response to Ang II are not well defined. Citations. A colony of social insects is not only an aggregation of individuals but also a functional unit. Therefore, significant efforts are urgently needed to identify pathophysiological function of YKL-40 in the dynamic interaction between tumor cells and TAMs in the tumor microenvironment, which may offer substantial mechanistic insights into tumor angiogenesis and metastasis, and also point to a therapeutic target for treatment of cancers and other diseases. We then monitored intra-cellular calcium in anti-CD34-FITC labeled satellite cells attached to muscle fibers using the calcium sensitive dye X rhod-1 which has little fluorescence cross talk with FITC. NIH. The impact score (IS), also denoted as Journal impact score (JIS), of an academic journal is a measure of the yearly . Neural factors. Objective and methods: Articles of this type must be submitted to a more appropriate clinical journal. About the Journal . Finally, we discuss the potential pathological implications of dysfunctional peroxisome degradation for human health. In contrast, intermediate doses of Ang II (200 and 400 ng/kg/min) while initially having no effect on systolic blood pressure were associated with significant increases in pressure over time. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to ... Echocardiography in MKT revealed a significantly higher percent wall thickening of the interventricular septum, a higher left ventricular (LV) fractional shortening, and a lower E/e(') (ratio of transmitral to annular flow) compared with CONT. Thanks to our authors, reviewers, and editors for accelerating scientific discovery and developing new solutions. Over the last decades, assessment of heart rate variability (HRV) has increased in various fields of research. Access Research Highlights. Power trained athletes have been shown to be more affected by fatiguing exercise than endurance athletes (Paasuke et al., 1999). Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Based on simple, physiologically realistic assumptions, flow-channel structure adapts so as to reach a configuration in which all parts of the tissue are supplied. Nitric oxide (NO) has many beneficial actions on the vascular wall including suppression of inflammation. Plant & Cell Physiology (PCP) was established in 1959 and is the official journal of the Japanese Society of Plant Physiologists (JSPP).The title reflects the journal's original interest and scope to encompass research not just at the whole-organism level but also at the cellular and subcellular levels. Please consider the content and article type specifications as stated below.
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